Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort

Barr PE, Bigdeli TB, Meyer JL, Peterson RE, Sanchez-Roige S, Mallard TT, Dick DM, Harden KP, Wilkinson A, Graham DP, Nielsen DA, Swann AC, Lipsky RK, Kosten TR, Aslan M, Harvey PD, Kimbrel NA, Beckham JC, & Million Veteran Program (MVP) Cooperative Studies Program (CSP). JAMA Psychiatry. doi:10.1001/jamapsychiatry.2023.4141

Executive Function and Impulsivity Predict Distinct Genetic Variance in Internalizing Problems, Externalizing Problems, Thought Disorders, and Compulsive Disorders: A Genomic Structural Equation Modeling Study

Gustavson DE, Morrison CL, Mallard TT, Jennings MV, Fontanillas P, Elson SE, Palmer AA, Friedman NP & Sanchez-Roige S. Clinical Psychological Sciences. doi: 10/1177/21677026231207845

Genome-Wide Association Studies of Coffee Intake in UK/US Participants of European Ancestry Uncover Gene-Cohort Influences

Thorpe HHA, Fontanillas P, Pham BK, Meredith JJ, Jennings MV, Courchesne-Krak NS, Vilar-Ribó L, Bianchi SB, Mutz J, 23andMe Research Team, Elson SL, Khokhar JY, Abdellaoui A, Davis LK, Palmer AA & Sanchez-Roige S. medRxiv. doi: 10.1101/2023.09.09.23295284

CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice: Sanchez-Roige S, Jennings MV, Thorpe HHA, Mallari JE, van der Werf LC, Bianchi SB, Huang Y, Lee C, Mallard TT, Barnes SA, Wu JY, Barkley-Levenson AM, Boussaty EC, Snethlage CE, Schafer D, Babic Z, Winters BD, Watters KE, Biederer T, 23andMe Research Team, Mackillop J, Stephens DN, Elson SL, Fontanillas P, Khokhar JY, Young JW & Palmer AA. Translational Psychiatry. doi: 10.1038/s41398-023-02453-y

Guidelines for Evaluating the Comparability of Down-Sampled GWAS Summary Statistics

Williams CM, Poore H, Tanksley PT, Kweon H, Courchesne-Krak NS, Londono-Correa D, Mallard TT, Barr P, Koellinger PD, Waldman ID, Sanchez-Roige S, Harden KP, Palmer AA, Dick DM, Linnér RK. bioRxiv. doi: 10.1101/2023.03.21.533641.

Shared genetic architecture between attention-deficit/hyperactivity disorder and lifespan

Vilar-Ribó L, Cabana-Domínguez J, Martorell L, Ramos-Quiroga JA, Sanchez-Roige S, Palmer AA, Vilella E, Ribasés M, Muntané G, Artigas MS. Neuropsychopharmacology. doi: 10.1038/s41386-023-01555-x

Multi-ancestry study of the genetics of problematic alcohol use in >1 million individuals

Zhou H, Kember RL, Deak JD, Xu H, Toikumo S, Yuan K, Lind PA, Farajzadeh L, Wang L, Hatoum AS, Johnson J, Lee H, Mallard TT, Xu J, Johnston KJA, Johnson EC, Galimberti M, Dao C, Levey DF, Overstreet C, Byrne EM, Gillespie NA, Gordon S, Hickie IB, Whitfield JB, Xu K, Zhao H, Huckins LM, Davis LK, Sanchez-Roige S, Madden PAF, Heath AC, Medland SE, Martin NG, Ge T, Smoller JW, Hougaard DM, Børglum AD, Demontis D, Krystal JH, Gaziano JM, Edenberg HJ, Agrawal A, Million Veteran Program, Justice AC, Stein MB, Kranzler HR, Gelernter J. medRxiv. doi: 10.1101/2023.01.24.23284960

Identifying problematic opioid use in electronic health record data: Are we looking in the right place?

Schirle L, Kwun S, Suh A, Sanchez-Roige S, Jeffery AD, Samuels DC. J Opioid Manag. doi: 10.5055/jom.2023.0754

Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders

Hatoum AS, Colbert SMC, Johnson EC, Huggett SB, Deak JD, Pathak G, Jennings MV, Paul SE, Karcher NR, Hansen I, Baranger DAA, Edwards A, Grotzinger A, Substance Use Disorder Working Group of the Psychiatric Genomics Consortium, Tucker-Drob EM, Kranzler HR, Davis LK, Sanchez-Roige S, Polimanti R, Gelernter J, Edenberg HJ, Bogdan R, Agrawal A. Nature Mental Health. doi:10.1038/s44220-023-00034-y

Correlates of Risk for Disinhibited Behaviors in the Million Veteran Program Cohort

Barr PB, Bigdeli TB, Meyers JL, Peterson RE, Sanchez-Roige S, Mallard TT, Dick DM, Harden KP, Wilkinson A, Graham DP, Nielsen DA, Swann A, Lipsky RK, Kosten T, Aslan M; Cooperative Studies Program (CSP) #572; Million Veteran Program, Harvey PD, Kimbrel NA, Beckham JC. medRxiv. doi: 10.1101/2023.03.22.23286865

Multi-ancestry meta-analysis of tobacco use disorders based on electronic health record data prioritizes novel candidate risk genes and reveals associations with numerous health outcomes

Toikumo S, Jennings MV, Pham B, Lee H, Mallard TT, Bianchi SB, Meredith JJ, Vilar-Ribó L, Heng Xu, Hatoum AS, Johnson EC, Pazdernik V, Jinwala Z, Leger BS, Niarchou M, Ehinmowo M, Penn Medicine BioBank, Million Veteran, Jenkins GD, Batzler A, Pendegraft R, Palmer AA, Zhou H, Biernacka JM, Coombes BJ, Gelernter J, Xu K, Hancock DB, Cox NJ, Smoller JW, Davis LK, Justice AC, Kranzler HR, Kember RL, Sanchez-Roige S. medRxiv. doi: 10.1101/2023.03.27.23287713

Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders

Hatoum AS, Colbert SMC, Johnson EC, Huggett SB, Deak JD, Pathak GA, Mariela Jennings J, Paul SE, Karcher NR, Hansen I, Baranger DAA, Edwards A, Grotzinger A, Substance Use Disorder Working Group of the Psychiatric Genomics Consortium, Elliot M Tucker-Drob EM, Kranzler HR, Davis LK, Sanchez-Roige S, Polimanti R, Gelernter J, Edenberg HJ, Bogdan R, & Agrawal A. Accepted at: Nature Mental Health doi: 10.1101/2022.01.06.22268753

Genetic investigation of the contribution of body composition to anorexia nervosa in an electronic health record setting

Mack T, Sanchez-Roige S, & Davis LK. Translational Psychiatry doi: 10.1038/s41398-022-02251-y

Parsing Genetically Influenced Risk Pathways: Genetic Loci Impact Problematic Alcohol Use Via Externalizing and Specific Risk

Barr PB, Mallard TT, Sanchez-Roige S, Poore HE, Linner RK, COGA Collaborators, Waldman ID, Palmer AA, Harden KP, Dick DM. Translational Psychiatry doi: 10.1038/s41398-022-02171-x

Substance use and common contributors to morbidity: a genetics perspective

Sanchez-Roige S, Kember, RL & Agrawal A. Lancet ebiomedicine doi: 10.1016/j.ebiom.2022.104212

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects on brain

Kember RL, Vickers-Smith R, Xu H, Toikumo S, Niarchou M, Zhou H, Hartwell E, Crist RC, Rentsch CT, Million Veterans Program, Davis LK, Justice AC, Sanchez Roige S, Kampman KM, Gelernter J, Kranzler HR. Nature Neuroscience doi: 10.1101/2021.12.13.21267480

Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci

Deak JD, Zhou H, Galimberti M, Levey DF, Wendt FR, Sanchez-Roige S, Hatoum AS, Johnson EC, Nunez YZ, Demontis D, Børglum AD, Rajagopal VM, Jennings MV, Kember RL, Justice AC, Edenberg HJ, Agrawal A, Polimanti R, Kranzler HR, Gelernter J. Molecular Psychiatry doi: 10.1038/s41380-022-01709-1

Cross-ancestry genomic research: time to close the gap

Atkinson EG, Bianchi SB, Ye GY, Martínez-Magaña JJ, Tietz GE, Montalvo-Ortiz JL, Giusti-Rodriguez P, Palmer AA, Sanchez-Roige S. Neuropsychopharmacology doi: 10.1038/s41386-022-01365-7

A phenome-wide association study of polygenic scores for attention deficit hyperactivity disorder across two genetic ancestries in electronic health record data

Niarchou M, Sealock JM, Straub P, Sanchez-Roige S, Sutcliffe JS, Davis LK. Neuropsychiatric Genetics doi: 10.1002/ajmg.b.32911

Polygenic Transcriptome Risk Scores Can Translate Genetic Results Between Species

Santhanam N*, Sanchez-Roige S*, Liang Y, Chitre AS, Munro D, Chen D, Cheng R, Gao J, George AM, Gileta A, Holl K, Hughson A, King CP, Lamparelli AC, Martin CD, Martinez AG, Mi S, St. Pierre CL, Tripi J, Wang T, Chen H, Flagel S, Ishiwari K, Meyer P, Saba L, Solberg Woods LC, Polesskaya O, Palmer AA, Im HK. bioRxiv *joint first authors doi: 10.1101/2022.06.03.494719

Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities

Mallard TT, Linner RK, Grotzinger AD, Sanchez-Roige S, Seidlitz J, Okay A, de Vlaming R, Meddens SFW, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Palmer AA, Davis LK, Tucker-Drop EM, Kendler KS, Keller MC, Koellinger PD, Harden KP. Cell Genomics doi: 10.1016/j.xgen.2022.100140

Accelerating opioid use disorders research by integrating multiple data modalities

Bianchi SB, Jeffery AD, Samuels DC, Schirle L, Palmer AA, Sanchez- Roige S. Complex Psychiatry doi: 10.1159/000525079

Identifying high-risk comorbidities associated with opioid use patterns using electronic health record prescription data

Jennings MV, Lee H, Rocha DB, Bianchi SB, Coombes BJ, Crist RC, Faucon A, Hu Y, Kember RL, Mallard TT, Niarchou M, Poulsen MN, Straub P, Urman RD, Walsh CG, PsycheMERGE Substance Use Disorder Workgroup, Davis LK, Smoller JW, Troiani V, Sanchez-Roige S. Complex Psychiatry doi: 10.1159/000525313

Evaluation of delay discounting as a transdiagnostic research domain criteria indicator in 1388 general community adults

Levitt EE, Oshri A, Amlung M, Ray LA, Sanchez-Roige S, Palmer AA, MacKillop J. Psychology Medicine doi: 10.1017/S0033291721005110

A mutant allele of Neuronal Membrane Glycoprotein M6-B (Gpm6b) facilitates behavioral flexibility but increases delay discounting

Sanchez-Roige S, Barnes S, Mallari J, Wood R, Polesskaya O, Palmer AA. Genes Brain & Behavior doi: 10.1111/gbb.12800

CADM2 is implicated in impulsive personality traits by genome- and phenome-wide association studies in humans, with further support from studies of Cadm2 mutant mice

Sanchez-Roige S, Jennings MV, Thorpe HHA, Mallari JE, van der Werf L, Bianchi SB, Lee C, Mallard TT, Barnes SA, Wu JY, Barkley-Levenson AM, Boussaty EC, Snethlage C, Babic Z, Winters BD, Watters KE, Biederer T, 23andMe Research Team, Mackillop J, Stephens DN, Elson SL, Fontanillas P, Khokhar JY, Young JW, Palmer AA. medRxiv doi: 10.1101/2022.01.29.22270095

Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders

Hatoum AS, Colbert SMC, Johnson EC, Huggett SB, Deak JD, Pathak G, Jennings MV, Paul SE, Karcher NR, Hansen I, Baranger DAA, Edwards A, Grotzinger A, Substance Use Disorder Working Group of the Psychiatric Genomics Consortium, Tucker-Drob EM, Kranzler HR, Davis LK, Sanchez-Roige S, Polimanti R, Gelernter J, Edenberg HJ, Bogdan R, Agrawal A. medRxiv doi: 10.1101/2022.01.06.22268753

Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts

Mallard TT, Savage JE, Johnson EC, Huang Y, Edwards AC, Hottenga JJ, Grotzinger AD, Gustavson DE, Jennings MV, Anokhin A, Dick DM, Edeberg HJ, Kramer JR, Lai D, Meyers JL, Pandey AK, Harden KP, Nivard MG, de Geus EJC, Boomsma DI, Agrawal A, Davis LK, Clarke T, Palmer AA & Sanchez-Roige S. American Journal of Psychiatry doi: 10.1176/appi.ajp.2020.20091390ere

Identifying high-risk comorbidities of short and long-term opioid prescription use

Jennings MV, Lee H, Rocha DB, Bianchi SB, Coombes BJ, Crist RC, Faucon A, Hu Y, Kember RL, Mallard TT, Niarchou M, Poulsen MN, Straub P, Urman RD, Walsh CG, PsycheMERGE Substance Use Disorder Workgroup, Davis LK, Smoller JW, Troiani V & Sanchez-Roige S medRxiv doi: 10.1101/2021.11.23.21266717

Two Data-Driven Approaches to Identifying the Spectrum of Problematic Opioid Use: A Pilot Study within a Chronic Pain Cohort

Schirle L, Jeffery A, Yaqoob A, Sanchez-Roige S, Samuels DC International Journal of Medical Informatics 156:104621. doi: 10.1016/j.ijmedinf.2021.104621

Genome-wide association study of problematic opioid prescription use in 132,113 23andMe research participants of European ancestry

Sanchez-Roige S, Fontanillas P, Jennings MV, Bianchi SB, Huang Y, Hatoum A, Sealock J, Davis LK, Elson SL, 23andMe Research Team & Palmer AA Molecular Psychiatry doi: 10.1101/2021.06.03.21258260

Dimensional phenotypes in psychiatric genetics: lessons from genome-wide association studies of alcohol use disorders

Mallard TT & Sanchez-Roige S Complex Psychiatry doi: 10.1159/000518863

Mapping Pathways by which Genetic Risk Influences Adolescent Externalizing Behavior: The Interplay between Externalizing Polygenic Risk Scores, Parental Knowledge, and Peer Substance Use

Kuo SI, Salvatore JE, Barr PB, Aliev F, Anokhin A, Bucholz KK, Chan G, Edenberg HJ, Hesselbrock V, Kamarajan C, Kramer JK, Lai D, Mallard TT, Nurnberger JI, Pandey G, Plawecki MH, Sanchez-Roige S, Waldman I, Palmer AA & Dick DM Behavior Genetics doi: 10.1007/s10519-021-10067-7

Multivariate analysis of 1.5 million people identifies genetic associations with traits related to self-regulation and addiction

Karlsson Linnér R, Mallard TT, Barr PB, Sanchez-Roige S, Madole JW, Driver MN, Poore HE, de Vlaming R, Grotzinger AD, Tielbeek JJ, Johnson EC, Liu M, Rosenthal SB, Ideker T, Zhou H, Kember RL, Pasman JA, Verweij KJH, Liu DJ, Vrieze S, COGA Collaborators, Kranzler HR, Gelernter J, Harris KM, Tucker-Drob EM, Waldman ID, Palmer AA, Harden KP, Koellinger PD & Dick DM Nature Neuroscience doi: 10.1038/s41593-021-00908-3

Alcohol and cigarette smoking consumption as genetic proxies for alcohol misuse and nicotine dependence

Sanchez-Roige S, Cox NJ, Johnson EO, Hancock DB & Davis LK Drug Alcohol Dependence doi: 10.1016/j.drugalcdep.2021.108612

Parsing Genetically Influenced Risk Pathways: Genetic Loci Impact Problematic Alcohol Use Via Externalizing and Specific Risk

Barr PB, Mallard TT, Sanchez-Roige S, Poore HE, Karlsson Linnér R, COGA Collaborators, Waldman ID, Palmer AA, Harden KP, Dick DM (2021) medRxiv doi: 10.1101/2021.07.20.21260861

Integration of Evidence across Human and Model Organism Studies: A Meeting Report

Rohan P, Johnson E, Won H, Polimanti R, Kapoor M, Chitre A, Bogue M, Benca-Bachman C, Parker C, Ursu O, Verma A, Reynolds T, Ernst J, Bray M, Kwon SB, Lai D, Quach B, Gaddis N, Saba L, Chen H, Hawrylycz M, Zhang S, Zhou Y, Mahaffey S, Fischer C, Sanchez-Roige S, Bandrowski A, Qing L, Shen L, Phillip V, Gelernter J, Bierut L, Hancock D, Edenberg H, Johnson EN, Barr P, Prins P, Smith D, Akbarian S, Thorgeirsson T, Walton D, Baker E, Jacobsen D, Palmer AA, Miles M, Chesler E, Emerson J, Agrawal A, Martone M, Williams R Genes Brain and Behavior doi: 10:1111/gbb.12738

Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies

Munn-Chernoff MA et al Addiction Biology doi: 10.1111/adb.12880

Polygenic contributions to alcohol use and alcohol use disorders across population-based and clinically ascertained samples

Johnson EC*, Sanchez-Roige S*, Acion L, Adams MJ, Bucholz KK, Chan G, Chao MJ, Chorlian DB, Dick DM, Edenberg HJ, Foroud T, Hayward C, Heron J, Hesselbrock V, Hickman M, Kendler KS, Kinreich S, Kramer J, Kuo SI, Kuperman S, Lai D, McIntosh AM, Meyers JL, Plawecki MH, Porjesz B, Porteous D, Schuckit MA, Su J, Zang Y, Palmer AA, Agrawal A, Clarke TK, Edwards A Psychological Medicine doi: 10.1017/S0033291719004045

A large-scale genome-wide association study meta-analysis of cannabis use disorder

Johnson EC, Demontis D, Thorgeirsson TE, Walters RK, Polimanti R, Hatoum AS, Sanchez-Roige S, Paul SE, Wendt FR, Clarke TK, Lai D, Reginsson GW, Zhou H, He J, Baranger DAA, Gudbjartsson DF, Wedow R, Adkins DE, Adkins AE, Alexander J, Bacanu SA, Bigdeli TB, Boden J, Brown SA, Bucholz KK, Bybjerg-Grauholm J, Corley RP, Degenhardt L, Dick DM, Domingue BW, Fox L, Goate AM, Gordon SD, Hack LM, Hancock DB, Hartz SM, Hickie IB, Hougaard DM, Krauter K, Lind PA, McClintick JN, McQueen MB, Meyers JL, Montgomery GW, Mors O, Mortensen PB, Nordentoft M, Pearson JF, Peterson RE, Reynolds MD, Rice JP, Runarsdottir V, Saccone NL, Sherva R, Silberg JL, Tarter RE, Tyrfingsson T, Wall TL, Webb BT, Werge T, Wetherill L, Wright MJ, Zellers S, Adams MJ, Bierut LJ, Boardman JD, Copeland WE, Farrer LA, Foroud TM, Gillespie NA, Grucza RA, Harris KM, Heath AC, Hesselbrock V, Hewitt JK, Hopfer CJ, Horwood J, Iacono WG, Johnson EO, Kendler KS, Kennedy MA, Kranzler HR, Madden PAF, Maes HH, Maher BS, Martin NG, McGue M, McIntosh AM, Medland SE, Nelson EC, Porjesz B, Riley BP, Stallings MC, Vanyukov MM, Vrieze S, Psychiatric Genomics Consortium Substance Use Disorders Workgroup, Davis LK, Bogdan R, Gelernter J, Edenberg HJ, Stefansson K, Børglum AD, Agrawal A Lancet Psychiatry doi: 10.1016/S2215-0366(20)30339-4

Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits

Zhou H, Sealock JM, Sanchez-Roige S, Clarke TK, Levey DF, Cheng Z, Li B, Polimanti R, Kember RL, Smith RV, Thygesen JH, Morgan MY, Atkinson SR, Thursz MR, Nyegaard M, Mattheisen M, Børglum AD, Johnson EC, Justice AC, Palmer AA, McQuillin A, Davis LK, Edenberg HJ, Agrawal A, Kranzler HR, Gelernter J Nature Neuroscience doi: 10.1038/s41593-020-0643-5

Steep Discounting of Future Rewards as an Impulsivity Phenotype: A Concise Review

Levitt E, Sanchez-Roige S, Palmer AA, MacKillop J Curr Top Behav Neurosci doi: 10.1007/7854_2020_128

Emerging phenotyping strategies to advance our understanding of psychiatric genetics

Sanchez-Roige S & Palmer AA Nature Neuroscience doi: 10.1038/s41593-020-0609-7

The Latent Genetic Structure of Impulsivity and its Relation to Internalizing Psychopathology

Gustavson D, Friedman N, Fontanillas F, Elson SL, 23andMe Research Team, Palmer AA, Sanchez-Roige S Psychological Science doi: 10.1177/0956797620938160

Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium

Polimanti R, Walters RK, Johnson EC, McClintick JN, Adkins AE, Adkins DE, Bacanu SA, Bierut LJ, Bigdeli TB, Brown S, Bucholz KK, Copeland WE, Costello EJ, Degenhardt L, Farrer LA, Foroud TM, Fox L, Goate AM, Grucza R, Hack LM, Hancock DB, Hartz SM, Heath AC, Hewitt JK, Hopfen CJ, Johnson EO, Kendler KS, Kranzler HR, Krauter K, Lai D, Madden PAF, Martin NG, Mes HH, Nelson EC, Peterson RE, Porjesz B, Riley BP, Saccone N, Stallings M, Wall TL, Webb BT, Wetherill L, Psychiatric Genomics Consortium Substance Use Disorders Workgroup, Edenberg HJ, Agrawal A, Gelernter J Molecular Psychiatry doi: 10.1038/s41380-020-0677-9

Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities

Recent efforts to dissect the genetic basis of alcohol use and abuse

Sanchez-Roige S*, Palmer AA, Clarke TK Biological Psychiatry doi: 10.1016/j.biopsych.2019.09.011

Phenome-wide investigation of health outcomes associated with genetic predisposition to loneliness

Abdellaoui A, Sanchez-Roige S, Sealock J, Treur JL, Dennis J, Fontanillas P, Elson S, 23andme Research Team, Nivard MG, Ip HF, van der Zee M, Baselmans BML, Hottenga JJ, Willsemsen G, Mosing M, Lu Y, Pedersen NL, Denys D, Amin N, van Dukin CM, Szlagyi I, Tiemeier H, Neumann A, Verweij KJH, Cacioppo S, Cacioppo JT, Davis LK, Palmer AA, Boomsma DI Human Molecular Genetics doi: 10.1093/hmg/ddz219

Genetic risk for major depressive disorder and loneliness in sex-specific associations with coronary artery disease

Dennis L, Sealock J, Levinson R, Farber-Eger E, Franco J, Fong S, Straub P, Hucks D, Song WL, Linton M, Fontanillas P, Elson S, Ruderfer D, Abdellaoui A, Sanchez-Roige S, Palmer AA, Boomsma D, Cox N, Chen G, Mosley J, Wells Q and Davis LK Molecular Psychiatry doi: 10.1038/s41380-019-0614-y

Electronic health records are the next frontier for the genetics of substance use disorders

Sanchez-Roige S* and Palmer AA Trends in Genetics 35(5):317-318. doi: 10.1016/j.tig.2019.01.007

Genome-Wide Association Studies of Impulsive Personality Traits (BIS-11 and UPPS-P) and Drug Experimentation in up to 22,861 adult research participants

Sanchez-Roige S, Fontanillas P, Elson SL, 23andMe Research Team, Gray GC, de Wit H, MacKillop J, Palmer AA Journal of Neuroscience 39(13):2562-2572. doi: 10.1523/JNEUROSCI.2662-18.2019

Genomic Basis of Delayed Reward Discounting

Gray JC, Sanchez-Roige S, de Wit H, MacKillop J, Weafer J & Palmer AA

Behavioral Processes 162:157-161. doi: 10.1016/j.beproc.2019.03.006

Genetic Influences on Delayed Reward Discounting: A Genome-wide Prioritized Subset Approach

MacKillop J, Gray JC, Weafer J, Sanchez-Roige S, Palmer AA & de Wit H

Experimental and Clinical Psychopharmacology doi: 10.1037/pha0000227

Genome-wide study identifies 611 loci associated with risk tolerance and risky behaviours

Linner RK et al bioRxiv doi: 10.1101/261081

Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts

Sanchez-Roige S, Palmer AA, Fontanillas P, Elson SL, 23andMe Research Team, Substance Use Disorder Working Group of the Psychiatric Genomics Consortium, Adams MJ, Howard DM, Edenberg HJ, Davies G, Crist RC, Deary I, McIntosh AM, Clarke TK American Journal of Psychiatry doi: 10.1101/275917

Trans-ancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders

Walters RK et al Nature Neuroscience doi: 10.1101/257311

Genome-wide association analysis of lifetime cannabis use (N=184,765) identifies new risk loci, genetic overlap with mental health, and a causal influence of schizophrenia on cannabis use

Pasman JA et al Nature Neuroscience doi: 10.1101/234294

Genome-wide association study of delay discounting in 23,217 adult research participants of European ancestry

Sanchez-Roige S, Fontanillas P, Elson SL, 23andMe Research Team, Pandit A, Foerster JR, Abecasis GR, Gray GC, de Wit H, Davis L, MacKillop J, Palmer AA Nature Neuroscience doi: 10.1038/s41593-017-0032-x

The genetics of human personality

Sanchez-Roige S, Gray GC, MacKillop J, Chi-Hua C, Palmer AA Genes Brain Behavior doi: 10.1111/gbb.12439

Genome-wide association study of Alcohol Use Disorder Identification Test (AUDIT) scores in 20,328 research participants of European ancestry

Sanchez-Roige S, Fontanillas P, Elson SL, 23andMe Research Team, Gray GC, de Wit H, Davis L, MacKillop J, Palmer AA Addiction Biology doi: 10.1111/adb.12574

Genome-Wide Association Study of Loneliness Demonstrates a Role for Common Variation

Gao J, Davis LK, Hart AB, Sanchez-Roige S, Han L, Cacioppo J, Palmer AA Neuropsychopharmacology doi: 10.1038/npp.2016.197

Heightened impulsivity: associated with family history of alcoholism, and a consequence of alcohol intake

Sanchez-Roige S, Stephens DN, Duka T Alcoholism: Clinical and Experimental Research doi: 10.1111/acer.13184

Mouse and human genetic analyses associate kalirin with ventral striatal activation during impulsivity and with alcohol misuse

Pena-Oliver Y, Carvalho FM, Sanchez-Roige S, … Schumann G, Stephens DN

Frontiers in Genetics doi: 10.3389/fgene.2016.00052

The novel mu-opioid antagonist, GSK1521498, reduces ethanol consumption in C57BL/6J mice

Ripley TL, Sanchez-Roige S, Bullmore ET, Mugnaini M, Maltby K, Miller SR, Wille DR, Nathan P, Stephens DN Psychopharmacology 232(18):3431-41. doi: 10.1007/s00213-015-3995-x

Voluntary Exercise Promotes Beneficial Anti-aging Mechanisms in SAMP8 Female Brain

Bayod S, Guzmán-Brambila C, Sanchez-Roige S, Lalanza JF, Kaliman P, Ortuño-Sahagun D, Escorihuela RM, Pallas M J Mol Neurosci 55(2):525-32. doi: 10.1007/s12031-014-0376-6

Alleviating waiting impulsivity and perseverative responding by µ-opioid receptor antagonism in two inbred mouse strains

Sanchez-Roige S, Ripley TL, Stephens DN Psychopharmacology 232(8):1483-92. doi: 10.1007/s00213-014-3786-9

Repeated ethanol exposure during early and late adolescence: double dissociation of effects on motor and choice impulsivity

Sanchez-Roige S, Peña-Oliver Y, Ripley T, Stephens DN Alcoholism: Clinical and Experimental Research 38(10):2579-89. doi: 10.1111/12535

Long-term wheel running changes on sensorimotor activity and skeletal muscle in male and female mice of accelerated senescence

Sanchez-Roige S, Lalanza JF, Alvarez-Lopez MJ, Cosin-Tomas M, Griñan-Ferré C, Pallas M, Kaliman P, Escorihuela RM AGE 36(5):9697 doi: 10.1007/s11357-014-9697-1

Exaggerated waiting impulsivity associated with human binge drinking, and high alcohol consumption in mice

Sanchez-Roige S, Baro V, Trick L, Peña-Oliver Y, Stephens DN, Duka T

Neuropsychopharmacology doi: 10.1038/npp.2014.151

Alpha-synuclein deletion decreases motor impulsivity but does not affect risky decision making in a mouse Gambling Task

Pena-Oliver Y, Sanchez-Roige S, Stephens DN, Ripley TL Psychopharmacology 231(12):2493-506. doi: 10.1007/s00213-013-3416-y

Macroautophagic process was differentially modulated by long-term moderate exercise in rat brain and peripheral tissues

Bayod S, Del Valle J, Pelegri C, Vilaplana J, Canudas AM, Camins A, Jimenez A, Sanchez-Roige S, Lalanza JF, Escorihuela RM, Pallas M J Physiol Pharmacol 65(2):229-239

Epigenetic alterations in hippocampus of SAMP8 senescent mice and modulation by voluntary physical exercise

Cosin-Tomas M, Alvarez-Lopez MJ, Sanchez-Roige S, Lalanza JF, Bayod S, Pallas M, Escorihuela RM, Kaliman P Frontiers in Aging Neuroscience doi: 10.3389/fnagi.2014.00051

Wnt pathway regulation by long-term moderate exercise in rat hippocampus

Bayod S, Menella I, Sanchez-Roige S, Lalanza JF, Escorihuela RM, Camins A, Pallas M, Canudas AM Brain Research doi: 10.1016/j.brainres.2013.10.048

Long-term exercise modulates hippocampal gene expression in senescent female mice

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