Jun 30 2021 - Sanchez-Roige Lab

2022

Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders

Hatoum AS, Colbert SMC, Johnson EC, Huggett SB, Deak JD, Pathak GA, Mariela Jennings J, Paul SE, Karcher NR, Hansen I, Baranger DAA, Edwards A, Grotzinger A, Substance Use Disorder Working Group of the Psychiatric Genomics Consortium, Elliot M Tucker-Drob EM, Kranzler HR, Davis LK, Sanchez-Roige S, Polimanti R, Gelernter J, Edenberg HJ, Bogdan R, & Agrawal A. Accepted at: Nature Mental Health doi: 10.1101/2022.01.06.22268753

Genetic investigation of the contribution of body composition to anorexia nervosa in an electronic health record setting

Mack T, Sanchez-Roige S, & Davis LK. Translational Psychiatry doi: 10.1038/s41398-022-02251-y

Parsing Genetically Influenced Risk Pathways: Genetic Loci Impact Problematic Alcohol Use Via Externalizing and Specific Risk

Barr PB, Mallard TT, Sanchez-Roige S, Poore HE, Linner RK, COGA Collaborators, Waldman ID, Palmer AA, Harden KP, Dick DM. Translational Psychiatry doi: 10.1038/s41398-022-02171-x

Substance use and common contributors to morbidity: a genetics perspective

Sanchez-Roige S, Kember, RL & Agrawal A. Lancet ebiomedicine doi: 10.1016/j.ebiom.2022.104212

Cross-ancestry meta-analysis of opioid use disorder uncovers novel loci with predominant effects on brain

Kember RL, Vickers-Smith R, Xu H, Toikumo S, Niarchou M, Zhou H, Hartwell E, Crist RC, Rentsch CT, Million Veterans Program, Davis LK, Justice AC, Sanchez Roige S, Kampman KM, Gelernter J, Kranzler HR. Nature Neuroscience doi: 10.1101/2021.12.13.21267480

Genome-wide association study in individuals of European and African ancestry and multi-trait analysis of opioid use disorder identifies 19 independent genome-wide significant risk loci

Deak JD, Zhou H, Galimberti M, Levey DF, Wendt FR, Sanchez-Roige S, Hatoum AS, Johnson EC, Nunez YZ, Demontis D, Børglum AD, Rajagopal VM, Jennings MV, Kember RL, Justice AC, Edenberg HJ, Agrawal A, Polimanti R, Kranzler HR, Gelernter J. Molecular Psychiatry doi: 10.1038/s41380-022-01709-1

Cross-ancestry genomic research: time to close the gap

Atkinson EG, Bianchi SB, Ye GY, Martínez-Magaña JJ, Tietz GE, Montalvo-Ortiz JL, Giusti-Rodriguez P, Palmer AA, Sanchez-Roige S. Neuropsychopharmacology doi: 10.1038/s41386-022-01365-7

A phenome-wide association study of polygenic scores for attention deficit hyperactivity disorder across two genetic ancestries in electronic health record data

Niarchou M, Sealock JM, Straub P, Sanchez-Roige S, Sutcliffe JS, Davis LK. Neuropsychiatric Genetics doi: 10.1002/ajmg.b.32911

Polygenic Transcriptome Risk Scores Can Translate Genetic Results Between Species

Santhanam N*, Sanchez-Roige S*, Liang Y, Chitre AS, Munro D, Chen D, Cheng R, Gao J, George AM, Gileta A, Holl K, Hughson A, King CP, Lamparelli AC, Martin CD, Martinez AG, Mi S, St. Pierre CL, Tripi J, Wang T, Chen H, Flagel S, Ishiwari K, Meyer P, Saba L, Solberg Woods LC, Polesskaya O, Palmer AA, Im HK. bioRxiv *joint first authors doi: 10.1101/2022.06.03.494719

Multivariate GWAS of psychiatric disorders and their cardinal symptoms reveal two dimensions of cross-cutting genetic liabilities

Mallard TT, Linner RK, Grotzinger AD, Sanchez-Roige S, Seidlitz J, Okay A, de Vlaming R, Meddens SFW, Bipolar Disorder Working Group of the Psychiatric Genomics Consortium, Palmer AA, Davis LK, Tucker-Drop EM, Kendler KS, Keller MC, Koellinger PD, Harden KP. Cell Genomics doi: 10.1016/j.xgen.2022.100140

Accelerating opioid use disorders research by integrating multiple data modalities

Bianchi SB, Jeffery AD, Samuels DC, Schirle L, Palmer AA, Sanchez- Roige S. Complex Psychiatry doi: 10.1159/000525079

Identifying high-risk comorbidities associated with opioid use patterns using electronic health record prescription data

Jennings MV, Lee H, Rocha DB, Bianchi SB, Coombes BJ, Crist RC, Faucon A, Hu Y, Kember RL, Mallard TT, Niarchou M, Poulsen MN, Straub P, Urman RD, Walsh CG, PsycheMERGE Substance Use Disorder Workgroup, Davis LK, Smoller JW, Troiani V, Sanchez-Roige S. Complex Psychiatry doi: 10.1159/000525313

Evaluation of delay discounting as a transdiagnostic research domain criteria indicator in 1388 general community adults

Levitt EE, Oshri A, Amlung M, Ray LA, Sanchez-Roige S, Palmer AA, MacKillop J. Psychology Medicine doi: 10.1017/S0033291721005110

A mutant allele of Neuronal Membrane Glycoprotein M6-B (Gpm6b) facilitates behavioral flexibility but increases delay discounting

Sanchez-Roige S, Barnes S, Mallari J, Wood R, Polesskaya O, Palmer AA. Genes Brain & Behavior doi: 10.1111/gbb.12800

CADM2 is implicated in impulsive personality traits by genome- and phenome-wide association studies in humans, with further support from studies of Cadm2 mutant mice

Sanchez-Roige S, Jennings MV, Thorpe HHA, Mallari JE, van der Werf L, Bianchi SB, Lee C, Mallard TT, Barnes SA, Wu JY, Barkley-Levenson AM, Boussaty EC, Snethlage C, Babic Z, Winters BD, Watters KE, Biederer T, 23andMe Research Team, Mackillop J, Stephens DN, Elson SL, Fontanillas P, Khokhar JY, Young JW, Palmer AA. medRxiv doi: 10.1101/2022.01.29.22270095

Multivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders

Hatoum AS, Colbert SMC, Johnson EC, Huggett SB, Deak JD, Pathak G, Jennings MV, Paul SE, Karcher NR, Hansen I, Baranger DAA, Edwards A, Grotzinger A, Substance Use Disorder Working Group of the Psychiatric Genomics Consortium, Tucker-Drob EM, Kranzler HR, Davis LK, Sanchez-Roige S, Polimanti R, Gelernter J, Edenberg HJ, Bogdan R, Agrawal A. medRxiv doi: 10.1101/2022.01.06.22268753

Item-Level Genome-Wide Association Study of the Alcohol Use Disorders Identification Test in Three Population-Based Cohorts

Mallard TT, Savage JE, Johnson EC, Huang Y, Edwards AC, Hottenga JJ, Grotzinger AD, Gustavson DE, Jennings MV, Anokhin A, Dick DM, Edeberg HJ, Kramer JR, Lai D, Meyers JL, Pandey AK, Harden KP, Nivard MG, de Geus EJC, Boomsma DI, Agrawal A, Davis LK, Clarke T, Palmer AA & Sanchez-Roige S. American Journal of Psychiatry doi: 10.1176/appi.ajp.2020.20091390